Fig 1: Systemic effects of HFD versus regular diet on mice serum cholesterol, LDL-C, PCSK9, and PSA levels. (A) Comparison of the HFD’s effect versus regular diet on mice mean serum total cholesterol levels. (B) Comparison of the HFD’s effect versus regular diet on mice serum LDL-C levels. (C) Comparison of the HFD’s effect versus regular diet on mice serum PCSK9 levels. (D) Comparison of the HFD’s effect versus regular diet on mice serum PSA levels. (E) Comparative of Western blotting analysis of HFD’s effect versus regular diet on the PCSK9 expression levels in CWR-R1ca cell tumors. (F) Western blot densitometric analysis of PCSK9 expression levels. Error bars represent the SEM for each experimental group. Each point is the mean of triplicate. **** p < 0.0001 for statistical significance compared to regular diet group. “ns” consider statistically not significant p > 0.5.
Fig 2: Systemic effects of PS treatments on mice serum cholesterol, LDL-C, PCSK9, and PSA levels. (A) Comparison of PS treatment effects on total serum cholesterol levels versus VC group. (B) PS versus VC treatment effects on mice mean serum LDL-C levels. (C) PS versus VC treatment effects on mice mean serum PCSK9 levels. (D) Treatment effects of PS versus VC on mice mean serum PSA levels. Error bars represent the SEM for each experimental group. Each point is the mean of triplicate. * p < 0.05, ** p < 0.01, for statistical significance. “ns” consider statistically not significant p > 0.5.
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